Inhibition of PBPs leads to defects in cell wall structure and irregularities in cell shape, for example filamentation, pseudomulticellular forms, lesions leading to spheroplast formation, and eventual cell death and lysis. Bacterial cell wall synthesis is essential to growth, cell division (thus reproduction) and maintaining the cellular structure in bacteria. PBPs are all involved in the final stages of the synthesis of peptidoglycan, which is the major component of bacterial cell walls. Proteins that have evolved from PBPs occur in many higher organisms and include the mammalian LACTB protein. The PBPs are usually broadly classified into high-molecular-weight (HMW) and low-molecular-weight (LMW) categories. The different PBPs occur in different numbers per cell and have varied affinities for penicillin. coli ranging in molecular weight from 40,000 to 91,000. For example, Spratt (1977) reports that six different PBPs are routinely detected in all strains of E. There are a large number of PBPs, usually several in each organism, and they are found as both membrane-bound and cytoplasmic proteins.
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